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Cardiolipin Antibodies (ACA) / Phospholipid Antibodies (APL)

Container:

Cardiolipin Antibodies (ACA) / Phospholipid Antibodies (APL)
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Reference Range:

Screen - Negative
Typing
IgG Normal = <10
IgM = <7

Turnaround Time:

10 working days

Comments:

Internal Test Code:- ACAB

Description:

Indication: Thrombosis, miscarriage

Background: Positive in the anti-phospholipid syndrome. May be primary or occur as a secondary complication of SLE. Elevated levels associated with recurrent spontaneous abortion, recurrent arterial/venous thromboses and thrombocytopenia. IgG ACA are more significant than IgM ACA.

Method: Enzyme Linked Immunosorbent Assay (ELISA)

Repeat Frequency: Cardiolipin antibodies are transiently positive in many infections. British Society Haematology guidelines require two positive tests for Cardiolipin, Beta2 glycoprotein 1 or lupus anticoagulant with a 12 week interval to diagnose antiphospholipid syndrome.
Borderline results should be repeated if high clinical index of suspicion of anti-phospholipid syndrome.

Preparation:

None

Vessels and Containers:

Serum gold-top

Sample Requirements:

500µl serum

Interference:

Recommended that grossly haemolysed or lipaemic samples should be avoided.

How result is reported:

Screen: Qualitative - Negative or See Typing (all positive screens will be typed for IgG and IgM cardiolipin antibodies)
Typing:Numeric in U/ml

Important Information:

Entry Last Modified 08/07/2019

Alias:

Anti Phospholipid Abs

Transportation and Handling:

At room temperature

Special Precautions:

None

Time limits for requesting additional examinations:

Sample available in this laboratory for approximately 2 weeks. Test can only be added to samples already received by Immunology.