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Endomysial Antibodies (EMA)

Container:

Endomysial Antibodies (EMA)
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Reference Range:

Negative

Turnaround Time:

7 working days

Comments:

Internal Test Code:- ENDA/ENDG
Please also see tTG/tissue transglutaminase antibodies

Description:

Indication:IgA - Confirmatory test following borderline/positive result for tissue transglutaminase (tTG) antibodies
IgG - Performed in suspected or known IgA deficient patients.

Background: EMA recognise tissue transglutaminase (tTG) and are used to confirm a positive tTG result. May be negative in children < 2 years old with coeliac disease, in whom IgG gliadin antibodies will be measured. IgA EMA are positive in > 90% of untreated adults with coeliac disease and in 60 - 70% of dermatitis herpetiformis patients. Rare in other enteropathies. Important in investigation of paediatric malabsorption. The antibodies disappear on gluten-free diet and thus may be used to monitor adherence to the diet. IgA EMA are absent in patients with IgA deficiency, who have an increased incidence of coeliac disease.

Method: Indirect Immunofluoresence (IIF)

Repeat Frequency: As clinically indicated.

Preparation:

None

Vessels and Containers:

Serum gold-top

How result is reported:

Negative or positive

Important Information:

Entry Last Modified: 22/05/2019

Alias:

Coeliac test

Transportation and Handling:

At room temperature

Special Precautions:

None

Time limits for requesting additional examinations:

Sample available in this laboratory for approximately 2 weeks. Test can only be added to samples already received by the immunology laboratory and within this time period.