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MuSK (Muscle Specific Kinase) Antibodies

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MuSK (Muscle Specific Kinase) Antibodies
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Reference Range:

Negative

Turnaround Time:

18 working days

Comments:

Internal Test Code:- MUSK

Description:

Indication: Myasthania Gravis

Background: Muscle specific tyrosine kinase (MUSK) is a surface membrane enzyme that is essential in aggregating Acetylcholine receptor during the development of the neuromuscular junction. Recent studies have shown that antibodies to Musk are present in 40% to 50% of patients with generalized Acetylcholine Receptor seronegative MG. Anti-Musk antibodies have not been found in patients with purely ocular myasthenia or in those with anti-acetylcholine receptor antibodies.

Method: Radioimmunoassay (RIA)

Repeat Frequency: As clinically indicated.

Preparation:

None

Vessels and Containers:

Serum gold-top
CSF not required

Sample Requirements:

500µl serum

Interference:

None known

How result is reported:

Qualitative (Negative or Positive)

Important Information:

Entry Last Modified:09/07/2019

Alias:

MUSK abs, Muscle specific tyrosine kinase abs

Reference Lab Description:

Immunology Department, The Churchill Hospital (Oxford)

Transportation and Handling:

At room temperature

Special Precautions:

None

Time limits for requesting additional examinations:

Sample available in this laboratory for approximately 2 weeks. Test can only be added to samples already received by Immunology. Please contact Immunology to add test to request. Direct contact with referral laboratory only may lead to a delay in result reporting.