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Ovarian Antibodies

Container:

Ovarian Antibodies
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Reference Range:

Normal result = Negative

Turnaround Time:

9 working days

Comments:

Internal Test Code:- OVAR

Description:

Indication:Autoimmune Premature ovarian failure.

Background: Cytochrome P450 enzymes involved in steroid biosynthesis are the targets of autoimmune attack against steroid producing cells. Antibodies that react with more than one of the 3 tissues tested (adrenal, ovarian and testicular) react with enzymes common to the hormonal synthetic pathways and are generally termed “steroid cell antibodies”. Ovarian antibodies are directed against P450scc enzyme. These antibodies may be cross-reactive with other steroid cell antigens. Several rare autoimmune endocrinopathy syndromes (PGA1, PGA2) are associated with these antibodies along with idiopathic Addison’s disease, premature ovarian failure, premature testicular failure and rare autoimmune pituitary failure. Absence of antibody does not rule out an autoimmune endocrinopathy, Results should be used with clinical symptoms, clinical history and other available data.

Method: Indirect Immunofluoresence (IIF)

Repeat Frequency: Not routinely required

Preparation:

None

Vessels and Containers:

Serum gold-top

Sample Requirements:

500µl serum

Interference:

None Known

How result is reported:

Reported as positive or negative

Important Information:

Entry Last Modified: 28/06/2019

Reference Lab Description:

Protein Reference Unit, Northern General Hospital (Sheffield)

Transportation and Handling:

At room temperature

Special Precautions:

None