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Paraprotein Quantitation


Paraprotein Quantitation
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Reference Range:

Normally negative.

Turnaround Time:

6 working days




Serum proteins are separated using capillary zone electrophoresis and any paraprotein/monoclonal band is measured by placing markers around the peak and calculating level as a percent of the total protein. This technique differs from that used routinely to quantify immunoglobulins, so that results of paraprotein quantitation may not correlate with routine immunoglobulin levels. Used to monitor disease progression and response to treatment Healthy adults do not have detectable paraproteins, but up to 20% of patients over 75 will have low levels of paraprotein (< 10 g/l). Chronic infection and inflammation may also cause low level paraproteinaemia.

Vessels and Containers:

Serum gold-top

How result is reported:

Positive results in g/l unless paraprotein runs in the beta region when the involved immunoglobulin level is reported. If the band is very small or in a polyclonal background, a comment is made.