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Eosinophil Cationic Protein (ECP)

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Eosinophil Cationic Protein (ECP)
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Reference Range:

1.0 - 15.0 µg/L

Turnaround Time:

9 Working Days

Comments:

Internal Test Code:- ECP

Description:

Indication: Eosinophilic inflammation (e.g. asthma)

Background: ECP is a highly cytotoxic protein found in eosinophil granules. Eosinophils are the cells chiefly responsible for producing the inflammation characteristic of asthma. When eosinophils in the airway are activated, they undergo degranulation causing airway epithelial damage and desquamation. This can increase hypersensitivity and lead to chronic inflammatory disease of the airway. ECP is released from the activated eosinophils during the inflammation process. Serum ECP levels have been shown to correlate with ECP concentrations in the bronch-alveolar lavage fluid, which in turn correlates with the severity of asthma. ECP can also be raised in atopic conditions such as allergic rhinitis.

Method: Fluoresence Enzyme Immunoassay (FEIA)

Repeat Frequency: As clinically indicated.

Preparation:

None

Vessels and Containers:

Serum gold-top

Sample Requirements:

500µl serum

Interference:

Plasma and haemolysed samples should not be used

How result is reported:

Numeric in µg/L

Important Information:

Entry Last Modified 21/06/2019

Alias:

ECP

Reference Lab Description:

Protein Reference Unit, Northern General Hospital (Sheffield)

Transportation and Handling:

At room temperature.

Special Precautions:

Blood samples should be allowed to clot for a maximum of 60 minutes before centrifugation and serum separation. Times in excess of this will result in artefactual elevation of ECP.

Time limits for requesting additional examinations:

This test cannot be added to existing requests. Please send a new request and sample.